In a study published in the National Library of Health, nitric oxide modulation of curcuma longa (turmeric) against sleep deprivation in mice was investigated.
The study looked at the possible role of nitric oxide in the protective effect of Curcumin (Curcuma longa) against 72-h sleep deprivation-induced behavioural alterations and oxidative damage in mice.
The study found that Curcumin extract treatment significantly restored depleted reduced glutathione, catalase activity, attenuated raised lipid peroxidation and nitrite level as compared to control (72-h sleep-deprived) animals.
It concluded: “The present study suggests that nitric oxide modulation is involved in the protective effect of Curcumin in ameliorating sleep deprivation-induced behavioural alterations and oxidative damage.”