Stress After Exercise Following The Lactate Threshold Can Be Surpassed

Researchers at the University of Tsukuba have found that physiological stress response to moderate-intensity exercise that occurs after the lactate threshold can be surpassed. The study was published in the journal, ‘Neuroendocrinology.’ The researchers have confirmed that arginine vasopressin and corticotrophin-releasing hormone regulate an important indicator of stress: the adrenocorticotropic hormone.

The adrenocorticotropic hormone (ACTH) is secreted, which involves the release of arginine vasopressin (AVP) and corticotrophin-releasing hormone (CRH) from hypothalamic neurons into the pituitary portal vessels. They used an established animal exercise-stress model to represent human physiological responses and blockers for each factor.

“This avoided the difficulties of earlier studies that had used blood samples only, and were unable to identify the causal relationship between ACTH and AVP and CRH responses during exercise stress,” explained Professor Hideaki Soya.

Because of the study’s design, the research team could evaluate each factor’s contribution separately and in combination, as well as factor-related activation in the brain, in response to the exercise protocol. AVP blockers and CRH blockers had an effect on ACTH release from the anterior pituitary only during running (not before running). Each blocker had an effect alone, yet a larger effect was observed when blockers were administered in combination.