In males, the spice required the insulin receptor substrate, CHICO, to extend its lifespan.
Females, however, did not require the substrate to extend their lifespan, which may be due to sex-specific differences in the insulin-like pathway.
The website Longevik, explains that “insulin signalling is an integral pathway in lifespan regulation, and cinnamon is able to repress it thereby promoting life extension”.
The health body continues: “Although we must take life extension studies in animal models with a grain of salt when it comes to human ageing, the conservation of biochemical pathways and gene homology between species indicates that promising compounds may exhibit similar effects in humans.”